While this may be related to local institutional practices, relevant processes must be put in place to maximize uniformity of practice and improve patient care. CONCLUSION: This study suggests that local protocols are often inconsistent with published evidence. An injection of calcium salt treats an overdose of magnesium sulfate, according to. Definitions of indications were consistent across sites, except for gestational age cut-off. Twenty of 25 centres provided protocols for fetal neuroprotection. Of 635 women with pre-eclampsia, 422 (66.5%) received MgSO4. Calcium Gluconate belongs to a class of drugs called Antidotes, Other Calcium Salts. Sixteen of the 22 sites with protocols had data from the CPN. Criteria for treatment and monitoring procedures varied across centres. Eleven of these provided a definition of preeclampsia that warranted treatment five of the 22 advised treatment of severe preeclampsia only. RESULTS: Twenty-two of the 25 centres submitted protocols for eclampsia prevention/treatment. Magnesium (antidote) is used to treat digitalis toxicity and hydrofluoric acid burns in adults and hypomagnesemia or torsades de pointes in pediatric. Data from the Canadian Perinatal Network (CPN) were used to verify what was done in clinical practice. Descriptive analyses were used to compare site protocols with known definitions of preeclampsia. However, clinical symptoms may be seen when the plasma magnesium concentration exceeds 4. When it occurs, the elevation in the plasma magnesium concentration is usually mild (<3 mEq/L, 3.6 mg/dL, or 1.5 mmol/L) and the patient is asymptomatic. Information abstracted included date of protocol, definitions of indications for treatment, details of MgSO4 administration, maternal and fetal monitoring, antidote for toxicity, and abnormal signs requiring physician attention. Hypermagnesemia is an uncommon problem in the absence of magnesium administration or kidney failure. METHODS: Twenty-five Canadian tertiary perinatal centres were asked to submit their protocols for use of MgSO4 for eclampsia prophylaxis/treatment and fetal neuroprotection. Thus, in order to explore standardization of MgSO4 use in Canada, we sought to compare local protocols for eclampsia and fetal neuroprotection across tertiary perinatal centres. Use of uniform, unit-established standing. Discussion about MgSO4 for fetal neuroprotection could not occur distinct from MgSO4 for eclampsia prophylaxis and treatment. Have standing orders for nurses to respond to signs and symptoms of magnesium toxicity, with quick access to antidote. A knowledge translation project to implement Canadian guidelines is ongoing. BACKGROUND: Magnesium sulphate (MgSO4) has been recommended for fetal neuroprotection to prevent cerebral palsy, with national societies adopting new guidelines for its use.
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